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KMID : 0545120080180071286
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Journal of Microbiology and Biotechnology
2008 Volume.18 No. 7 p.1286 ~ p.1289
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Interference of In Vitro and In Vivo Growth of Several Intestinal Bacteria by Lactococcus Strains
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Kimoto-Nira Hiromi
Ohmomo Sadahiro
Masaru Nomura
Miho Kobayashi
Koko Mizumahi
Takashi Okamoto
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Abstract
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The ability of Lactococcus strains to inhibit the growth of intestinal bacteria was examined. In in vitro cocultures, we observed that among eighteen Lactococcus strains tested, the ability to inhibit growth of Escherichia coli varied, with the L. lactis N7 showing the greatest growth inhibition. Strain N7 (8.94×1010 CFU/day for 7 days) was orally administered to mice, and the viable count of strain N7 in feces appeared at a level of 104-5 CFU/g. After administration, the proportion of Bacteroidaceae to total intestinal bacteria decreased. Lactococci may act as probiotic bacteria by inhibiting the growth of harmful bacteria.
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KEYWORD
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Probiotics, lactococci, growth inhibition, intestinal microflora
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